How to effectively resist oxidation
As the first barrier of our human body, skin condition is also the most intuitive manifestation of our age and physical health.
Due to long-term exposure to sunlight and air, some microorganisms, radiation, cosmetics, etc. can cause oxidative reactions in the skin, producing a harmful compound - free radicals, which can cause skin aging. To resist free radicals, it is necessary to enhance the skin's antioxidant capacity in order to achieve the goal of anti-aging.
So what does skin antioxidant mean? How to effectively resist oxidation?
1.What does antioxidant mean?
Antioxidation refers to the abbreviation of antioxidant free radicals. The human body continuously produces free radicals in the body due to continuous contact with the outside world, including respiration (oxidation reaction), external pollution, radiation exposure, and other factors. The mechanism of action of natural antioxidants is mainly manifested in the following four aspects: ① directly clearing ROS. Most natural antioxidants contain phenolic hydroxyl groups, which react with ROS to generate stable quinone like substances, terminate the chain reaction and clear the ROS already produced by the body; ② Inhibiting the reaction of lipid peroxidation; ③ Chelated metal cations indirectly resist oxidation; ④ Activate antioxidant signaling pathways such as Nrf2/Keap1/ARE.
2. Skin oxidative damage related skin diseases
UV damage related skin diseases
The mechanism of photosensitization is that endogenous or exogenous photosensitizers absorb ultraviolet light from the ground state to the excited state, leading to further reactions that cause reactive oxygen species (ROS), ROS and reactive nitrogen specifications, The formation of RNS. The main ROS produced after UV radiation are hydroxyl radicals, superoxide anions, hydrogen peroxide radicals, and their active precursors, namely singlet oxygen, hydrogen peroxide, and ozone. After UV irradiation, fibroblasts continuously produce ROS and non enzymatic substances such as ascorbic acid, tocopherol, panthenol, and glutathione, GSH and other antioxidants of enzymes (such as catalase, superoxide dismutase, thioredoxin reductase, glutathione peroxidase, etc.) can maintain a balance between prooxidants and antioxidants, leading to cellular structural stability.
Pigmented skin disease
ROS inhibits melanin synthesis by upregulating the expression of tyrosinase genes; Or it can affect the adhesion of melanocytes to the extracellular matrix and inhibit melanocyte proliferation; And melanocytes in pigmentary skin diseases are highly sensitive to oxidative stress.
Fungal infectious skin disease
When pathogenic fungi such as Aspergillus fumigatus, Candida albicans, and Cryptococcus invade the body, they encode SOD GSH-Px、 Antioxidants such as thioredoxin antagonize oxidative stress damage caused by ROS.
Erythromatous papular scaling skin disease
Psoriasis is an immune-mediated polygenic chronic inflammatory skin disease, and its occurrence and development are related to oxidative stress damage.
3. What are the effects of antioxidants?
Under normal circumstances, the production and clearance of intracellular ROS are in a subtle dynamic balance. Imbalance of cellular oxidative stress can trigger various skin problems, such as UV induced skin aging and increased skin melanin levels. To a certain extent, antioxidant properties delay the occurrence and development of these skin problems.
What are free radicals?
Reactive oxygen species (ROS) include free radicals such as superoxide anions (O ₂ ⁻), hydrogen peroxide (H ₂ O ₂), lipid peroxides, and nitrogen oxides. Cellular oxidative metabolism includes various enzymes and non enzyme substances, such as mitochondrial electron transport chains, cyclooxygenases, peroxidases NADPH oxidase and lipoxygenase, etc.
4. Differences between antioxidant and anti-aging, skin whitening
Anti aging is comprehensive, and antioxidant is subordinate to anti-aging; Antioxidation can help anti-aging, but anti-aging is not just anti-oxidation. More than 90% of women believe that antioxidant, like basic care, is almost a lifelong care. Antioxidants capture and eliminate free radicals, playing a role as the skin's bodyguard. The bodyguard's job is to defend against external damage, arrest invading snacks, and antioxidant can delay aging. Aging is only a result of oxidation, so there is an intersection between antioxidant and anti-aging. However, antioxidant itself has a large scope, and anti-aging is not just a problem that can be solved by antioxidant alone.
Regarding skin whitening, in some melanotic diseases, oxidative stress factors mainly pass through the NO pathway caused by UVB The p53 pathway activated by DNA photooxidative damage works together, leading to an imbalance in intracellular oxidative stress levels, more pronounced melanin accumulation, and the formation of pigment deposition. Antioxidant therapy methods such as glutathione, traditional Chinese medicine, and vitamin C use reducing functional groups as hydrogen donors to neutralize ROS and improve oxidative stress levels in patients; On the other hand, it is also possible to inhibit the activity of tyrosinase, a key rate limiting enzyme in melanin synthesis, by competitively combining copper ions and adjusting the pH environment, thereby reducing the generation and accumulation of melanin and achieving good whitening effects.
5. The principle of antioxidation
Antioxidant is any substance that can effectively inhibit the oxidation reaction of free radicals in the presence of low concentrations. Its mechanism of action can be direct action on free radicals, or indirect consumption of substances that are prone to generating free radicals to prevent further reactions.
6. What can help the skin resist oxidation?
Natural food antioxidants mainly exist in the following types of food:
● Foods rich in anthocyanins: blueberries, pomegranates, purple cabbage, purple sweet potatoes, grapes, red chili peppers, blood oranges, cherries, cranberries, strawberries, mulberries, etc;
● Foods rich in vitamin E: almonds, wheat germ oil, cottonseed oil, corn oil, sesame oil, kudzu leaves, cabbage, cauliflower, celery, chili peppers, tomatoes, etc;
● Foods rich in vitamin C: lemon, prickly pear, kiwifruit, grapefruit, celery, guava, etc;
● Foods rich in flavonoids: oranges, green tea, grapes, red wine, apples, and berries, etc;
Foods rich in beta carotene: carrots, spinach, lettuce, broccoli, cantaloupe, winter melon, green tea, etc.
In addition, during the antioxidant period, it can also be combined with internal adjustment products rich in vitamin C to reduce melanin deposition, eliminate free radicals, regulate from the inside out, help the skin resist oxidation, and improve skin problems such as acne.
Xi'an Hersoncare Bio-Tech Co., Ltd